The “hook effect” causing a negative pregnancy test in a patient with an advanced molar pregnancy

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The “hook effect” causing a negative pregnancy test in a patient with an advanced molar pregnancy

•At high hCG levels in molar pregnancies, a "hook effect" can cause an artificially negative value.•Delay in diagnosis of a molar pregnancy due to the "hook effect" can lead to severe complications.•Suspicion of a molar pregnancy should be communicated so a diluted sample is used to quantify hCG.

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Molar pregnancy with false negative urine hCG: the hook effect.

Urine pregnancy tests are widely used in emergency departments as the first screening test for patients of reproductive age presenting with gynaecological problems in order to rule out pregnancy. Conditions such as complete molar pregnancy, which produces large amounts of beta human chorionic gonadotropin (beta-hCG), may cause a false negative result due to an oversaturation of the assay system...

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Pulmonary Metastatic Choriocarcinoma in a Patient with Ectopic Pregnancy

Gestational trophoblastic tumor (GTT) most commonly follows a molar pregnancy. In fact, it can occur following gestational events such as induced or spontaneous abortion, ectopic pregnancy, and term pregnancy. In this study, we present the case of a patient with ectopic pregnancy who was treated with a single dose of methotrexate (MTX). The maximum titer of beta subunit of human chorionic gonad...

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Partial molar ectopic pregnancy: A case report

Partial or complete mole affects one in 1000  pregnancies.Partial mole is a rare form of ectopic pregnancy. There was a married woman,gravid 4,parity 1,abortion 1,and she had past medical history 0f right ectopic pregnancy.she had left ectopic pregnancy and was treated by laparascopic left salpyngectomy after failure of intramascular methotrexate treatment.After surgery  the pathology exam show...

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Successful Pregnancy in a Chronic Hemodialysis Patient

Pregnancy in end stage renal disease women who are on Hemodialysis has been considered a challenging event for both mother and fetus. Generally, outcomes of pregnancy in patients with end-stage renal disease (ESRD) have been considered to be extremely poor, and pregnancy in this group of patients is rather scarce. The frequency of conception is ranged from 0.3% per year in Belgium to 1.4% per y...

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ژورنال

عنوان ژورنال: Gynecologic Oncology Reports

سال: 2017

ISSN: 2352-5789

DOI: 10.1016/j.gore.2017.06.008